Sclerotic chronic Graft versus Host Disease
I have a young patient with chronic GVH disease, sclerotic type, presented with progressing, extensive, painful skin ulcers at torso, arms and legs, with a referral for hyperbaric oxygen therapy. Biopsy is consistent with fibrosis and GVH, no malignancy. She has been treated with Prednisone (since 1/2011), ECP (d/c 1/2012), sirolimus (d/c 8/2012), imuran (d/c 12/2012), rituximab (d/c 8/2012), tacrolimus (last 5/2013), methotrexate (since 5/2013), IL-2 (since 2/2013). Her primary, diffuse, large B-cell lymphoma seems to be in remission since 2007.
I could not find any data in literature that could give me any information if HBO2T might have any benefit on her case. I was wondering if you have any insight or knowledge you can share with us on this subject.
Nilufer Norsworthy, MD
Northwest Hospital, Seattle, WA