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Sclerotic chronic Graft versus Host Disease
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10/2/2013 at 10:40:51 PM GMT
Posts: 1
Sclerotic chronic Graft versus Host Disease

Dear colleagues,

I have a young patient with chronic GVH disease, sclerotic type, presented with progressing, extensive, painful skin ulcers at torso, arms and legs, with a referral for hyperbaric oxygen therapy.  Biopsy is consistent with fibrosis and GVH, no malignancy. She has been treated with Prednisone (since 1/2011), ECP (d/c 1/2012), sirolimus (d/c 8/2012), imuran (d/c 12/2012), rituximab (d/c 8/2012), tacrolimus (last 5/2013), methotrexate (since 5/2013), IL-2 (since 2/2013). Her primary, diffuse, large B-cell lymphoma seems to be in remission since 2007.

I could not find any data in literature that could give me any information if HBO2T might have any benefit on her case.  I was wondering if you have any insight or knowledge you can share with us on this subject.


Nilufer Norsworthy, MD

Northwest Hospital, Seattle, WA

10/16/2013 at 3:38:28 PM GMT
Posts: 2
Try a TCOM with O2 challenge?
I have no literature to offer, but would suggest a TCOM with O2 challenge, and then a physician to physician contact with the insurance company.

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