All,I have a 33yo female patient being treated for ORN using the Marx protocol of 20/10 treatments. During the first 20 treatments the patient complained of tenderness and throbbing pain to bilateral breasts and upper lateral thighs. She shows a lot of mottling post treatment to her thighs and breasts without any itchiness. She said the pain is not associated with her menstrual cycle and does not feel the same type of tenderness that she feels during menstruation. She is not pregnant.She was away from hyperbaric therapy for six days to have her extractions and reported that the pain/tenderness went away during her time off. She returned for hyperbaric treatment on Monday and today reported that the pain had returned after just 3 treatments. I went online and found two cases of tender/painful breast that where diving related (DCS) and that resolved with hyperbaric therapy, however I was not able to find any information, nor have I ever heard of tender or painful breast associated with hyperbaric oxygen therapy for female patients.I’m at a loss and don’t know how to explain this to the patient. Have any of you heard of anything like this or know the cause? Psychosomatic?As always, any help would be greatly appreciated.